As an advocate for mushroom cultivation and research, Paul Stamets is a legend in the world of mycology. Stamets has spent decades exploring and researching mushrooms, identifying new species, pioneering techniques in mushroom cultivation, and encouraging others to embrace the power of mushrooms as a healing medicine. Source

One of the key insights that Stamets’ 2018 patent application highlights is the concept of “stacking.” Stacking refers to the practice of pairing non-psychoactive substances with psilocybin microdoses in an attempt to enhance and expand upon the effects of the latter. The most well-known and popular Stamets stack combines Lion’s Mane functional mushroom, Niacin (vitamin B3), and psilocybin in either mushroom or truffle form.

The reason this combination is considered a powerful brain enhancing supplement is because of the synergistic effect of these ingredients together. Both Lion’s Mane and Niacin act as inhibitors of monoamine oxidase, meaning they prevent the breakdown of serotonin in the brain, extending and amplifying its effects. The vasodilating properties of niacin also allow it to cross the blood-brain barrier and deliver Lion’s Mane and psilocybin directly to neurons, where they can exert their most potent effects.

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In addition, erinacins and herinacins found in Lion’s Mane are neurotransmitters that stimulate nerve growth factors and help to promote neurogenesis, which is crucial for brain health. As with any supplement or microdosing protocol, it is important to approach this stack slowly and carefully, monitoring your own personal reactions to ensure the optimal experience. It is generally recommended to follow a schedule of four active dosing days followed by three integration (no dosing) days.